The match, which will kick off at 5pm BST, will be Everton’s final game before they kick off the Premier League season at home to Southampton the following weekend.
This is the third pre-season friendly Everton have announced so far, after they revealed they will play two games in Orlando against Millionarios and either Arsenal or Inter Milan in the Florida Cup in late July.
Current COVID-19 guidelines mean that tickets for the United friendly will be initially only be available to a limited number of home fans, but a restricted number of Everton fans will also be able to attend if restrictions are eased as expected on July 19.
Everton will announce further information concerning ticket details on their official website in due course.
The Blues, who have yet to replace Carlo Ancelotti as manager three weeks on from his decision to leave Goodison Park to return to Real Madrid, drew 3-3 at Old Trafford last season in February.
Everton - summer 2021 timeline
Tue 1 - Carlo Ancelotti leaves Everton
Wed 9 - Summer transfer window opens
Mon 5 - Everton’s non-international players scheduled to begin pre-season training
Sat 10 - 2021 Copa América finishes
Sun 11 - Euro 2020 finishes
Sun 25 - Everton vs Millionarios (pre-season Florida Cup semi-final - other semi between Arsenal and Inter Milan, kick-off 8:30pm EST [1:30am BST])
Wed 28 - Florida Cup final and third place play-off
Sat 7 - Manchester United vs Everton (pre-season friendly, kick-off 5pm BST)
Sat 14 - Everton vs Southampton (Premier League season begins)