The Toffees, who have yet to replace Carlo Ancelotti as manager following his move to Real Madrid on June 1, will kick off the new season by facing Ralph Hasenhuttl’s side at Goodison Park during the weekend of August 13-15.
It means Everton’s Premier League fixture list starts with a home match for the first time in four years.
Everton’s first away game of the season comes the following weekend, and will be against Leeds United.
Goodison clashes with Burnley (September 11) and Norwich City (Sep 25), as well as trips to Brighton (Aug 28) and Aston Villa (Sep 18) complete Everton’s opening six league fixtures.
The first meeting with Liverpool of the season will take place at Goodison on Tuesday, November 30, with Jurgen Klopp’s men hosting the reverse fixture on April 23.
The festive period sees Everton visit Burnley on Boxing Day, while they welcome Brighton to Goodison on New Year’s Day, with a home game against Newcastle sandwiched in-between on Tuesday, December 28.
If Nuno Espirito Santo, the current favourite for the Everton job, is indeed appointed, he will reconvene with previous club Wolverhampton Wanderers on October 30 at Molineux and March 12 at Goodison.
The run-in for the Blues consists of home ties against Crystal Palace (April 16), Chelsea (April 30) and Brentford (May 15) and visits to Liverpool (April 23) and Leicester (May 7), before the campaign concludes with an away clash with Arsenal on Sunday, May 22, 2022.
The first set of fixture changes for television coverage are likely to be announced in early July.