Most notably, the Blues may have to deal with the absence of James McCarthy. The 25-year-old is struggling to make it after picking up a hip injury against Bournemouth.
Having already missed the victory over Middlesbrough in mid-week, the Ireland international now faces a late fitness test ahead of the key clash. If Roberto Martinez manages to mastermind three points against the Eagles, then the Toffees will leapfrog five teams - including Liverpool - in to sixth place in the Premier League.
If McCarthy doesn't make it, then it could mean a chance for either Tom Cleverley (who deputised against Middlesbrough), Muhamed Besic, or Darron Gibson alongside Gareth Barry in central midfield.
Meanwhile, Leighton Baines is unlikely to play a part in the match. Despite having featured in the Capital One Cup, the England international is set to be eased back in to action. A luxury afforded by Brendan Galloway's great form since being given regular football.
However, there is also one addition to the long term injury list of Phil Jagielka, Tony Hibbert, Steven Pienaar, and Bryan Oviedo.
It has been revealed that Tyias Browning is facing a lengthy spell on the sidelines after undergoing surgery on a knee injury. The 21-year-old picked up the problem while playing against Blackburn Rovers for the Under 21's last season.