Roberto Martinez has called on the supporters to provide the players with some "TLC" after the weekend loss at White Hart Lane.
The game has taken on greater significance because of that defeat, with Everton having little margin for error in the race for a top four spot.
They will begin the game as favourites against a Crystal Palace side 15th in the table, but the Eagles arrive on Merseyside in good form having flourished under new boss Tony Pulis.
They have won three out of their six league games since the turn of year and enjoyed a profitable transfer window, giving the fans genuine hope they can avoid relegation from the Premier League for the first time.
The predicted wet and windy weather should also play into Pulis' hands, meaning it is unlikely to be pretty at Goodison this evening.
We will bring you all the team news when they are announced in the comments section below. Please have your say on the game too when the action kicks off at 7:45pm UK time.